I'm a seasoned photo-traveler, although much less in the last few years due to the dollar's devaluation in tandem with an onslaught of personal expenses.
One time I traveled to national parks with 35mm and medium-format plus an assortment of film and lenses for both, and a tripod sturdy enough to hold the Pentax 67. I had a rental car, otherwise I would've been hopelessly overburdened. Traveling to Europe where I was typically on a train, bus, metro, etc. I wouldn't consider two formats. I tried it once with a Hasselblad and 3 lenses and 2 backs, and while it wasn't too heavy, it was very bulky. Getting through crowds, on and off busses and metro was clumsy at best. Any hope of blending in was impossible, I stood out like a sore thumb, if not an outright spectacle.
After that I used only a small 35mm SLR (Pentax) outfit, until I couldn't focus it well enough anymore. I couldn't arrange to fit diopters on the old Pentax, so I went to a "modern" SLR. Unfortunately those had bloomed over the years into an outfit no less bulky than the Hasselblad. That's when I fell back on my trusty M4 that I'd bought around 1970 but really hadn't used much because of the limited range of lenses at the long end. But for the last ten years of film photography I used Leica M exclusively for travel, and got used to the quirks. Leica's aren't light weight, but they are compact, and being able to get 2 bodies and 6 lenses into a narrow little bag was a revelation. In fact many times I left the bag at the hotel and just carried my outfit in a sport jacket outfitted with zippered security pockets. It's so nice to be able to stop in a cafe for lunch and be able to de-lens my camera and stow everything in my jacket. With an SLR I always had the darn thing in my lap. I can't remember the last time I carried a full-sized tripod, either. The Leica table-top job can be braced against any vertical surface like a wall, lamp post, or tree. I even devised a way to use graduated filters (before Photoshop came along).
Transitioning to the digital age I got an M8...just in time to stop traveling! Now that the bulk of my photography is close to home I've mainly gone back to an SLR and the Leica is mostly back on the shelf.