Depends on the monitor frankly. Some can do D50 no problem. I have used both off and on over the years, again, depending on the monitor. Back in the day the CRT monitors that were made could easily be set for D50 and for color matching that was the best so it became the standard. Over the years monitor backlighting has changed which throws a wrench in the works. From CRTs to Fluorescent to LEDs. My advice for what to use would depend on what you are doing with your computer. If you print then D50 would be the way to go but only if you can get there. Judging prints needs to be done the right way as well if you go down the proverbial rabbit hole, so you need a viewing booth or a full spectrum light source optimized for the task. Basically that is how professionals have been doing it for decades. At home you are probably better off using dead reckoning. Look at your print under various lights and see if you have a problem. Keep in mind too that most prints will be viewed under a 3200 source, but today there are many "daylight" bulbs too. My point to this is unless you are under controlled conditions it is a bit of a crapshoot. If you are not printing then it isn't as critical because your eye will adapt to the brightest white in your vision, so as long as the brightest white is on the monitor and you have it calibrated and profiled, you will see pretty accurate color regardless of the white point you have set.
