In close up photography the first things to consider is 'field size' and 'working distance'.
Field size; What are you going to photograph? How small is it?
OK, lets say it is a postage stamp, a flat, 1 inch square piece of artwork. This means that you will be working at an image to object ratio of 1:1 or close to that. With extention tubes used on a 50mm f1.8 Zuiko lens the total extention would have to be about 41mm with the lens helical making up the final 7~9mm of extention you would need to fill the frame.
At that extention 'working distance' in front of the lens would be about 3 inches. That would be about as much as one would want to push the standard 50 1.8 lens and working aperture for that ratio would probably be set to no more than f8 (with full 50mm extension actual stop is f16 with lens at f8)
With larger field sizes or larger 3D objects the constraints would be less. Extention tubes often come in sets such as 7mm-14mm-36mm and these can be combined, along with the lens own focusing travel to produce a large range of close up photography from 1:10 right on down to 1:1
The advatage of a dedicated macro lens such as the aformentioned 50mm f3.5 Zuiko is that it, in many circumstances, can be used as your standard lens and can focus right down to 1:2, and, with a 25mm extension tube, from 1:2 down to 1:1
Dedicated macro lenses are also designed for working very close and are sharper than the standard 50 f1.8 when working in the close focusing range.