If you or a family member or friend works for a major American corporation you might investigate donating through their charitable program...most of them will do some kind of match if you do, and none will deduct anything for handling...typically they pass the money through to American Red Cross or United Way, both of which are highly efficient.
I mentioned on P.N that Bank of America will match dollar for dollar...if you give $50 they will add 50, for example. I think that's typical of many corporations. Naturally, a nitwit objected to mention of that bank :bang: but this is the real deal, peoples attitudes notwithstanding :bang: ...BofA and other corps do this well, supercharging your donation. Their match is in fact literally a donation at the expense of shareholders. :angel:
There'd be no tax deduction for you, but you might consider asking your bank branch manager or some other officer you may know (eg management or lender or stockbroker type) to make the donation for you , to get that donation leveraged. 😉