Smaller lenses and smaller aperture openings both make for greater depth of field. If you're into "bokeh" then smaller lenses may not interest you. However, 110 lenses of small size and f4.5 or greater often don't need much focusing adjustment to have every depth in acceptable focus. This is why so many 110 cameras are focus free.
However, there were some 110 cameras with quality optics and quality focusing mechanisms. My first camera, the Pentax Auto 110, can resolve very well and can be focused very precisely with all of its lenses... well, except for the one pan-focus lens offered. I never bothered buying that lens. The maximum aperture is f2.8 for all its lenses, so low light will require a flash.
The Kodak Pocket Instamatic 60 also offers great optics and a fairly easy-to-use rangefinder. It too has good resolving power and can be focused precisely. Its f2.7 lens also isn't the best for low light photography, so a flash is handy.
My Minolta Weathermatic-A is a view camera with lower resolving power and only five zones for the focus... all selectable with icons. Aperture is f3.5, so it it relies a built-in flash, and has a fairly broad depth of field. There's no discernible bokeh with this camera.
My Canon 110ED 20 has a fairly fast f2.0 lens and an excellent rangefinder. It has pretty good resolving power and works fairly well in low light. I've actually gotten some good bokeh on bright days when focusing up close.
My Voigtländer Vitoret 110 (my second one because the first broke when shooting its first roll) has a fairly small aperture of f5.6 so it is effectively an infinitely variable zone focus view camera. Its viewfinder shows only three depth icons, and depth of field is very great... almost pan-focus. I've never seen any bokeh with this camera. It is only useful in bright sunlight, and even a living room in daylight gets the low exposure warning lit.
My Rollei E110 uses a moderate f2.8 aperture, so low light photography requires a flash or a tripod. I haven't seen any bokeh with this camera, and focusing is very forgiving... which means that it has pretty good depth of field. I also have a Rollei A110, but its film advance broke halfway through my first roll of film, which was a real disappointment.
So, that's my experience with 110. Comparatively, 35mm cameras have much less depth of field, especially at larger aperture openings.
Scott