I use a medium-sized Chrome Citizen messenger bag. It accommodates a 15" MBP Retina in a padded sleeve, and can hold 1-2 RF-sized cameras plus lenses, with pockets for all sorts of junk. And if you can tolerate the "hipster effect" that these bags can have, you'll find that they are super comfortable and do not look like they're full of valuable electronics.
When you see bike messengers riding in cities, many of them have Chromes strapped to their back. It's because they have to wear their bags all day...I've never experienced another messenger bag as comfortable as this. Did I also mention they are very well made? My Citizen is 8 years old, has been to four continents, and gets carried on bicycle rides, motorcycle rides, and while travelling. I use it to carry a camera and laptop to the office every day. Other than the usual scuffs or small flaws any bag can be expected to pick up over time, it is still rock solid without a single busted seam or tear.
I love Chrome bags because they are lined (interior and exterior "flap") with military grade truck tarpaulin. It's easily the heaviest-duty waterproof lining I have ever seen on a bag that isn't a Pelican case. That lining means there's no silly elastic-banded shell to pull out if you're in the pouring rain to waterproof your bag; you just step out into the elements, confident that your expensive crap is safe. My bag has kept said expensive crap 100% dry, even on the freeway in a motorcycle in the rain, or walking through hurricane-level weather at home in Hawaii. The Citizens are so waterproof we used to fill ours with ice and cold beers in a pinch, because the liner is just that solid.
I've also recently acquired a Niko Camera Messenger bag. It holds an X-Pro, 55-200mm, 14mm, 23mm, & 35mm along with batteries, filters, an external strobe, etc in a nice, not so camera-baggy-looking package:
http://www.chromeindustries.com/us/en/bags/camera-bags/niko-messenger
No room for a laptop in the Niko, however.
🙁
Given the smaller capacity and use of zippers, I don't expect the Niko to be as robust or useful as my Citizen Messenger bag. But so far it's kept my stuff bone dry, and it's hurricane season here right now.
There's a bag with a dedicated laptop sleeve built-in as well, but honestly it's basically a normal Chrome Messenger with a sleeve sewn in:
http://www.chromeindustries.com/us/en/bags/laptop-bags/mini-buran
These are a lot cheaper than those camera bags that scream "Hello there I'm a camera bag!" (*cough* Billingham *cough*), and Chrome includes a lifetime warranty against defects, so if you factor that in they're a great deal.
One word of warning though: My 8 year old bag was made in the USA, and definitely feels more robust than my new Chrome Niko camera bag, which was made in China...and apparently all newer Chrome messengers are not made in the USA anymore. But again, with a lifetime warranty I suppose it doesn't matter. Hope this helps!
