I rarely shoot with high ISO's.
My brother, however, needs high ISO's. His option in many cases is either bulky Night Vision or no picture. Each model of digital camera has reduced the number of cases where he has to make that decision. He is currently testing the 1Dx and at 50,000 its shadow noise was less than the 5d Mk2 at 6400. He was showing me the side by side photos and the difference was amazing.
For people who need these high ISO sensors, these advances are changing the way they work. And for them its a huge step forward. For those who do not, they are benefiting from improved sensors and image processors. I think it is a win for everyone.