I don't believe that either of these lenses is multi-coated. The I-50's were made in the mid-1960's, before multi-coating was commonly available. The _22's were made in the 1950's.
Maizenberg says that the I-50 has higher resolution than the I-22, but he doesn't say why.
I've made enlargements from ISO 100 color negative film up to 8X12 and cannot see any distinctions at that level of enlargement. Perhaps it will show at higher maginifications.
-Paul