It sounds like from your earlier post, you bought the camera. If so, and if you are willing to spend a bit more time before tossing it out the window!
Initial start-up is slow but Leica M10 is not immediate as M cameras of old. Once it's on, start-up from sleep is quicker.
Getting rid of extra info on screen is easy to cycle through and then leave it parked in simple screen mode.
Cycling through ISO if you don't set to auto is quite simple and programming it once will allow quick access actually to ISO and other useful functions.
Auto focus works fine for my purposes, not sure what the issue is there.
Switching to B&W or Vivid should that interest you is a breeze with the thumbwheel.
As for handling, obviously this is personal, but I find with addition of thumbs up (and maybe also a grip), the camera feels really good and is beautifully constructed. Unlike the Leica Q, Sony provides nice molded rubber for the thumb and then for fingers on front of the body. The grip eliminates access on the front side. The RX1RII easily finds a place with any camera I've had for a variety of applications and is nice companion when I want one camera/lens along without taking up much space -to say nothing of image quality.
David