Let's just say that many scanning applications/plug-ins leave at least a bit to be desired on the UI front. The ones offered by scanner manufactuerers are a bit more slick in some ways, but in some ways they might not offer the fine-tuning ability of VueScan or Silverfast.
When I worked at a photo agency, we used Silverfast for everything (main scanners were an Epson 1600 flatbed and Nikon LS 1000). It was a love-hate thing for me. For my own work at home, I went for VueScan and never looked back. Yes, the early UI was daunting, but for me it worked; The current iteration has gone through a lot of changes, and I daresay most have been much for the better. Yes, there are a lot of options, which for me is a Good Thing, but if you consider yourself a bit allergic to all those option menus, you can always use the "fewer options" setting, which simplifies things a lot.
The real beauty of VueScan is that one scanning app covers a ton of scanners, new and old, flatbed, dedicated-film, and everything in-between. Unlike Silverfast, Mr. Hamrick doesn't force you to purchase a different copy for each scanner you own. It costs about $40 for the standard version, about $80 for the Pro version, but if, like me, you bought VueScan back before there was a Pro version, you got a free upgrade to Pro for no extra cost. And, for me it was worth every dime.
I do use the software that came with my Minolta 5400 from time to time, but VS gets the nod four times out of five. It always gets used with my UMAX tabloid flatbed, even though I have a standing order for the new, OS X-compatible version of UMAX' MagicScan software, and have yet to hear from them on my order.
- Barrett