They still focus the same distance between the lens flange to the sensor, so an F/4.5 lens is still an F/4.5 lens, just with a smaller sensor that intercepts only the center portion of the image, giving you an angle of view equivalent to a lens of twice the focal length on a FF 35mm format camera.
This is assuming that your M/u43 adapter is machined to proper dimensions and tolerances. There have been some reports of issues with certain brands of adapters; you'll have to search this and other sites for info re: adapter brands.
Don't be surprised if you find the resulting images less than what you would otherwise expect; many of these wide angle RF lenses produce soft edges and corners on u/43, due to the sensor requiring a more telecentric lens design, such that the light strikes the pixels more directly. The Lumix 20-F1.7 lens outperforms many of these legacy lenses, albeit with software correction included.
~Joe