If you're using plastic reels, it's especially important to agitate sufficiently while fixing to ensure it gets to all parts of the film. As you probably know, you can test your fixer by immersing a snip of exposed film leader. Watch how long it takes the film to clear and double that time to get your minimum fixing time for film. Personally, if it takes more than 5-6 minutes for my film to clear, I'll mix up a fresh batch of fixer.