http://www.hamrick.com/vuescan/html/vuesc19.htm#topic16
If you set the RAW file to save at the time of Scan then it bypasses all color corrections. It's saved as if it were just sent to the memory buffer. You'll probably get better results by setting the output color space (Color Tab in Vuescan) to what Photoshop uses. I assume that's AdobeRGB but I could be wrong on that.
One thing that Vuescan would do to the file if you let it process in Vuescan is adjust for the color of the film base. I don't believe there's a way natively to do this in Photoshop. There is a plug-in that you can purchase that's designed to get around this, but I'm not exactly certain that it is. Anyways here's a tutorial with links to the plug-in in case you feel like giving it a try (trial is free with watermarks of course).
http://benneh.net/blog/2010/09/25/vuescan-colorperfect-a-guide/?goal=yes
edit: same plugin as kanzlr refers to.
I'm getting ahead of myself here though. There's a few settings that you should consider:
1. If you have scan from preview set (Input tab) turn that off. The preview is what lets the program see the density of the film and adjust the exposure accordingly. Taking that away is like shooting everything at a sunny 16 setting on your camera.
2. Try increasing your preview resolution. With the preview being the only basis on what to adjust anything to, you may need to give the program more pixels to calculate from.
3. On the Crop tab set the Buffer% to 15% or above. I've found that 5% get's too much of the vignetting that occurs to most lenses.
4. Color tab, Scanner color space set to Adobe RGB.
5. Color Balance, typical settings (by typical I mean usually works but sometimes not) would be Auto Levels for outdoor daylight scenes, White Balance or manually selecting a white balance spot for indoor or flash lit scenes, Neutral for most scenic (non portrait) scenes like cityscapes and landscapes, and Night or None for most night time cityscapes. None is also what I use for Multi-Exposure (on scanners capable of it). Multi-Exposure is usually reserved for underexposed slides or overexposed negatives. It helps, but is no magic bullet.
Again, if you're outputting a raw file most of this is skipped completely. Raw files were intended to delay the processing and get on with creating proper basic (raw) scans in a timely manner.
Gamma is something I've yet to come to grips with. It's briefly talked about at
http://www.hamrick.com/vuescan/html/vuesc23.htm#topic20 but when I look elsewhere on the web via google or where ever I'm not sure that Gamma is the same as how Ed is referring to it.