Again, does Vuescan does any of this better?
I never quite got the hang of Vuescan but you could just try it out yoursef. You can test it for free but your scans will have a watermark across the image.
If you indeed have the Silverfast SE version and not the Ai version you could, of course, upgrade but I'm somewhat skeptical that you'll be happy with it. The Negafix profiles aren't really what one would expect, i.e. making the film look "right". It's more like they give the scan a certain look that they decided is what fits a certain film stock. Sometimes it looks good, a lot of times it takes a considerable amount of tweaking.
As far as I know the SE version of Silverfast lets you scan in Silverfast RAW format. Since NegativeLabPro now supports Silverfast RAW files I would give that plugin a try. (Again, I think you can try it out for free.)
The whole idea behind film profiles is somewhat questionable the more you think about it. As you've pointed out, there's no reason why setting the profile to VC should increase saturation. The "vivid color" should be present in the negative, not in the scanner profile. One would expect that all a profile does is compensate for the orange base of the specified film. However, as I've mentioned, the tint of the orange base can vary quite a lot depending on the age and/or storage of the film so it's not possible to have a fixed software setting that always works.
I share your aggravation about scanning and I also have a hard time getting the colors right. What's interesting, though, is that I don't really have those problems in the color darkroom. I can see quite quickly what has to be tweaked and can get the colors right more easily than when I'm working with a scan. With a darkroom print either it looks good or it doesn't. With a scan, though, often I like some things in the image and others not. Like, the midtones are good, but the highlights are off, or the greens are nice but the blues are off etc. etc. And every time I tweak what's wrong it throws off something else.