Vacation with 50mm only: is it possible?

Has anyone ever gone on a vacation with a 50mm only?

Yes, but it was not my first choice. If forced to take only one prime lens on vacation, here is what I would choose (in order of priority):

35mm f/1.4 (Zeiss on Leica M6 rangefinder)
35mm f/2 (Nikkor on Nikon F4 SLR)
40mm f/1.7 (Canon Canonet QL17 G-III rangefinder)
45mm f/2 (Zeiss Planar on Contax G1 rangefinder)
50mm f/1.4 auto focus (Nikkor on Nikon F4 SLR)
50mm f/1.4 (Takumar on Pentax Spotmatic SLR)
50mm f/1.8 Series E (on Nikon EM SLR)

However, if given a choice, I would rather take a low-cost, mid-range zoom (such as an 18-55mm f/3.5 to 5.6 on an APS-C dSLR body.
 
Earlier this year I drove cross country and took a Nikon DSLR with 28mm, 50mm and 200mm lenses and a Leica MP with 28mm, 50mm and 90mm lenses. Except for two cities, all of this was landscape photography. I estimate that I made 90% of the shots with the 50s and 5% each with the 28mm and 200mm (didn't use the 90mm)

As pointed out above, what you bring depends on where you will be shooting. I'd say a 50mm would be the most versatile lens and would not be difficult to use for almost all purposes, unless you will be doing mostly urban shooting, in which case a 28mm or 35mm would be better.

I'm doing a long weekend in NYC later this year and plan on taking one camera and either a 28mm or a 35mm.
 
I've done that, in fact just rolling with a 50mm lens or equivalent depending what you're using, reduces decision making, your back will thank you because you're lugging a whole bunch of lenses around and force you to look for shots that will fit this focal length. It is actually a really good exercise.
 
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