This may not sound like a very sophisticated approach, but don't overlook just turning up the edge-enhance setting in the "Film" presets.
I started out with this turned to the minimum level, because I had been taught dogmatically that "sharpening is the last step in your workflow." But when I set it back to the normal level, I got substantially sharper-looking results without any real penalty that I could see.
If you shoot in raw mode, you can experiment with different edge-enhance settings during raw file conversion and see which one seems best suited to your subject and shooting conditions.