Like night and day at high ISO with my A57, maybe not with a camera that has better high ISO performance. Also, many people say that LR supports some cameras better than others. Nikon and Canon is what I usually hear mentioned, but I don't have any personal experience with that issue.
Still, I probably should mention that is about the only thing I liked with DXO. Their interface just seems perverse at times to me, but I assume you can get used to it.