I voted "no," but I did have a scare over the summer while on vacation, which led to a frantic thread here. I inadvertently forgot to remove about 40 rolls of film, some exposed, most not, from a bag that I checked on flight from Stockholm to Oslo. Fortunately, the bag does not appear to have been x-ray'd, b/c the film all turned out fine (I had a couple of rolls processed in Oslo to make sure). For the remainder of the trip, I made sure the film was in my carry-on bag and I asked for hand inspection at every airport. The only airport that refused to hand-inspect was Heathrow.
From the responses to my thread in July, I understand that x-ray damage to film in carry-on bags is minor but cumulative, in that repeated exposure to x-rays at security check points may over time result in detectable damage to the film itself (but see x-ray's post above). If your film goes into checked luggage, it will be a goner unless you luck out like I did and the airport did not x-ray the bag.