I would agree with Mike that the ASPH has better edge sharpness, but if you look at say the flickr pool, maybe 5% or less are really focused at the edges. For people shots, they're usually not at the edge, more center.
landscapes wide open would probably be better with the asph, but there are few of these to see. The bokeh is different, but not necessarily harsh or bad on the asph, just different. I've seen a lot of great photos from the lux asph, but many more from the pre-asph, could be because the pre-asph has been around about 50 years longer.
It's nice that they made an E43 verison with proper focus ring that takes the reversible hood, but I think that is a limited LHSA version only. The basic main product loses all the mojo of the original and is really just evil, IMHO, short focus throw and all.