I've got a friend who is using 24/2.8 ASPH, 35/1.4 ASPH, and CV 15/4.5 on the X-Pro1. He's happy as a clam and doing terrific work on the street with that setup. I'm using the native 18 and 35 lenses; I'm also using a 21 Biogon on an adaptor.
MF works very well in both cases IF you learn how to use it properly.
With legacy glass: Push in on the thumbwheel on the back of the camera to get the magnified EVF. This works even when you are framing through the OVF. Half-press the shutter once you've focused and you're in OVF or EVF framing mode again. Lickety split.
With native glass: once in MF mode you get close by hitting AF-L, then fine-adjust using the ring on the lens. Very fast, quite intuitive. Also, it's worth noting that the focus throw on the 18/2 is much shorter than on the 35/1.4.