Scanning software should be used only to digitally capture the maximum amount of information contained on the film. Then an image processing program such as Photoshop or LightRoom is used to manipulate that data into the best looking print. Often the best final results are derived from a file direct from the scanner that looks horribly bad being flat without much contrast. But those are the scan files that contain the most data and ultimately yield the best final results.
There are settings in most scanner software to get a reasonable looking result direct from the scanner with no image processing. Consider them the same as a overall reflective light meter feeding into a camera's auto shutter speed, auto f stop, auto iso, and auto focus. They give an equivalent to a basic point and shoot result which is good enough sometimes.
Personally, over 16 years of scanning negatives, I have always found that Vuescan digitizes the most data from the film and Photoshop works best for image processing. YMMV.