My Domke F5XB is packed with a Minolta CLE, a Leica M4-P, 28, 35, 40, 50 & 90mm lenses plus film and the usual extra junk. After about 15-20 years it doesn't show much wear. Have an 803 bag about the same age that travels a lot and it looks fine. Have a very old FX3 canvas bag with a couple of holes and pulled stitches, and an F6 that takes a D750 and three or four lenses. The bag looks fine, but the insert could stand some repair.
I wouldn't have any hesitation buying a Domke, unless they've changed a lot in the past 10 years.