I've been using Domke bags since 1999 when I used to work at Looking Glass camera store in Berkeley, Cailfornia. I was the "bag salesman" and I remember there were only really two options, Lowepro or Domke. Today we have a lot of choices on the market, but I still use Domke bags as my 'go to' bag. I've never thought (or heard) about waxing them, but next time I'm in a camera store that sells Domke bags I'll take a look at the waxed bags. I like to shoot in the rain and I don't mind when my bag gets wet, just as long as my gear inside stays dry.
I do own an Artist and Artisan bag that I bought here for a really good price, I use that when I'm out and about in Bangkok, because it looks a lot nicer than my beat up, ripped and stained Domke bag, but I feel the Domke is made better.
Cheers, michael