My methods change with the seasons. I have a refurbished Epson 3170 I bought in 2005. The lights in the head are getting dimmer and wearing out. I've scanned over 5000 unique negatives with it to date. Most at 3200dpi. Those two light tubes have been on for countless hours at this point.
THIN negatives scan better than thick ones for me now, thanks to this. I still shoot thick, since I plan on having printable negs in the future.
Anyway, here's my really ignorant and simple-minded approach:
I use the Epson software in Windows XP. I open up the histogram window and slide the sliders to the end of the 'mountain' on both sides. This gives me the highest contrast without killing shadows and highlights. I scan.
In photoshop I open up the .tif file I created and I crop&rotate to get things nicely aligned and read for some work. I typically do auto levels and see if that looks good. If not, I open up the curve and pull it around at three points to adjust the shadows, highlights, and midtones.
Then I use a plugin called Fred Miranda's Web Presenter Pro to do a size down to 1600 pixels wide for my Flickr uploading. It sizes down without creating jagged marks on stuff.
So that's it. Each 35mm frame at 3200dpi takes about 3 minutes. Medium format stuff get scanned at 1800dpi takes about 5 minutes of my time. I am very much a 'good enough' sort of guy.
If I was working at exhibiting my photos, A) I'd probably wet print them in my darkroom, or B) pay someone else to do it right, who has proper training.
I literally stumble through the dark because I'm too stubborn to sit down and read a book, and find that there are 1000 ways to arrive at a very similar conclusion, so why waste time listening to ONE book?
I don't do layers, I don't dodge and burn, I DO clone out dust specks occasionally. I still think it's important to actually know how to expose your negatives correctly. Then you won't need to spend much time layering and darkening the sky or whatnot.
As for color work? I spend time with the color sliders to make the photos look JUST HOW I WANT THEM. I don't fool myself into thinking that Fuji Superia 400 has to look like Fuji Superia 400. I make it look how I want it, not how internet purists think it's supposed to look. Anyone who does PROFESSIONAL work at a photography shop will tell you that their pro grade work has been modified greatly to look its best.
Purists. They're only kidding themselves the moment they poke the 'SCAN' button.
I remember someone emailed me to bitch that this is not what Fuji Provia 100 looks like:
Oh well. That's what the shot looked like in my mind.