I agree with Barrett on the ease of scanning Portra film. I used a Nikon Coolscan and Nikon software until switching to a 64 bit OS. Nikon will not suport 64 bit operation, so enter Vuescan. Other than not being able to use a lot of the Coolscan's features, Vuescan works OK. My old method was to scan the film at 4000 dpi with the Nikon software and do the final adjustment/sizing as required in Photo Shop. Make an extra effort to make the film as dust free as possible (ditto for the scanner). With Vuescan the scans are OK, but I am thinking of resurrecting my old computer (with 32 bit OS) and dedicating it scanning only with the Nikon software.
Mike