Thanks for more suggestions. The Tamrac looks interesting. The waistpack might work in conjunction with storing it in a backpack for the traveling bits. Also will look at the Golite bags.
To further clarify, I'm not actually hiking - usually in urban environments. At the same time, I'm usually out all day on my feet, camera in hand. It's not very practical to leave camera equipment back at the room for fear of theft, so I tend to bring it with me. I've learned the lesson of traveling with too much crap, but at the same time, I'd rather not go without a backup body. It's not a lot of equipment, 2 RF bodies, 3-4 lenses, film, and meter, plus any other normal supplies I might need: fleece pullover, book, water, etc. At the same time, from my last trip to Japan, my messenger bag was killing me after 10 hours. Its great for travel, as a carry on, or for a couple hours out, but I'm finding it leaves something to be desired for a 10 hour day when it's packed to the brim.
I don't really need a real full blown photo backpack - they look way to serious to me and usually provide too much space for photo gear.