I bought the lens for the look it produces wide open, and so I shoot it wide open unless DOF or light issues force me to stop down. Probably 75%or more of my use of the Sonnar is for portraiture. I have never had the focusing issues that have been so extensively discussed on these forums, any misfocus in my photos always seems to be operator error, and I can pretty much predict a poor result coming as I snap the shutter. I usually choose an alternative 50mm lens (or MF) when I want that super sharp clinical look, but can pretty near equal that quality with the Sonnar stopped down. Easily my most commonly used 50mm lens, and the last one I would give up.
LJS