This depends heavily on how far out it is.
I've done minor horizontal adjustments this way on a couple of later Kievs, but if there's a particularly extreme adjustment necessary, it involves a total tear-down and a lot of trial-and-error while you play around with prism positions and the gearing between the RF mechanism and the lens mount. And if vertical alignment is out, there's absolutely no simple fix - you need to dissolve some glue to adjust and reposition a prism, and hope that it doesn't shift slightly while the glue sets. It's an absolutely ridiculous design that always makes me think Zeiss' engineers were somewhat arrogant: it seems they made it assuming that it'd never go wrong, instead of designing it in a way that it would be easily adjustable when it did.
Meanwhile, with both the screwmount Leica and the FED 2, you don't need to disassemble anything significant - just remove a single cover screw and a RF bezel/surround. You can get a rangefinder from completely out of whack to within spec in less than 10 minutes on a FED 2 if you know what you're doing - and you don't have to know much!