There's a rule of thumb regarding diffraction, which is never use an aperture smaller than one-quarter of the focal length. Oops!
I borrowed a friend's 12 and shot tests on Velvia 50, and using a 22x loupe could find no appreciable difference from 5.6 through 11 (except, of course, for vignetting).
By 16 things began looking slightly less well defined, but the difference was not dramatic. This was essentially the same pattern I found with my 15mm.
I hope this illustrates that you'd have no worries with enlargements up to 16x20 at any aperture on this lens.