Truly uncoated lenses -- not just single-coated -- have much lower contrast, more flare, and poorer shadow differentiation (because of the flare).
Yes, I have a few uncoated lenses, and the bigger the format, the better they work, but with 35mm, the only uncoated lens I habitually use is my 1938 Thambar -- which is soft and flary anyway, because it's a soft-focus lens. In larger formats I quite like my 165mm f/6.8 Dagor on 13x18 cm/5x7 inch and my 21 inch (533mm) f/7.7 Ross on 8x10 inch.
Also, of course, a vast amount depends on the subject and the lighting.
Cheers,
R.