I have two of the m645 1000's and one m645...pretty much identical except that the 1000s has a top speed of 1/1000, has a self-timer and DOF preview button...
Like the others have stated, no removable backs but the roll changes go pretty quickly...there are prisms with meters (very accurate), a meterless prism and the WLF...
I have the Metered Prism and several WLFs...for vertical shot the prisms work best but with the WLFs you can get unusual angles and it opens up a whole lot of different shooting...
I have the 45, 55, 70 w/shutter, 80 1.9, 110, 150, 145 soft focus and 210 lenses....
I just got the 70mm and haven't used it yet...I love the 45, 55 and 110 lenses especially with the WLF...
The m645 runs off of one readily available 6v battery (just keep a spare handy), the body is heavy but you get used to it and it balances well with many of the lenses...it has two shutter buttons...one on top which can be a pain in the butt (I tend to mistakenly trip that one at times) and one in front on the bottom right side (also has a lock)...
It has a Mirror Lock Up switch and a Multi (exposure) switch...the Red button on top is your Battery Check...and there are two connection for flash sync X & FP.
To open the back door you push in where the film reminder goes then slide the button with the arrow on it...
There's a winder you can get for it too...I got mine cheap because it didn't work (broken wires) and was missing the piece that connects the body to the winder...I have it all now and it works just fine...a bit heavy I might add...
The lenses have rabbit ears like the Nikon lenses and when only using the metered prisms you have to make sure they engage properly or your meter will give you a wrong reading...
Also be sure to check the Prism finders for the "Line" on the mirror...you'll read that because of the glue used in assembly the silver on the mirror may be delaminating...
https://www.flickr.com/groups/mamiya645/discuss/72157625772382552/
Here's a link to the manual...
http://www.mamiyaleaf.com/assets/files/documentation/M645_1000S_v4.pdf