Jamie123
Veteran
I used to be a tourist, and now live here. I think Tim-n hits it right on the head when he points out your interests will help define the best area.
My first trips were all in the Union Square area and Financial District, but the neighborhoods are much more diverse in a number of ways.
San Francisco is really two cities in one -- a cosmopolitan city overlaid on a set of small villages, really.
I would avoid Fisherman's Wharf, Pier 39, etc if you want a sense of the living, breathing San Francisco.
On the other hand, I also agree that transport in the city gives you quick access to a lot of areas.
If, like Tim N and me, you like to mingle with real folk, or have special activities that define your tourist perspective, let us know and people can be helpful in pointing out what gets you best access.
What sets San Francisco apart from a lot of cities is our diversity -- in terms of population, food, and neighborhoods.
We are at the center of a food revolution that lets you eat fresh and interesting food at prices my European visitors find incredibly low, we have an explosion of food trucks and street food, we have a cults around differences in coffee, and baristas have rock star followings, we are experiencing a flowering of interesting, unusual, and downright peculiar artinasal ice cream. But you can reach those from anywhere in the city -- the question is taking a bit of time to decide what you care about and then checking up where they are and how to get there.
Also unusual is the diversity of Asian cuisines -- not just Chinese, but regional Chinese, and Vietnamese, Cambodian, Thai, etc.
You can spend all your meals seeing how these different cuisines treat fish.
But maybe food isn't your main travel attraction. What is?
I love food so good restaurants are always high on the list. As I said in my reply to Tim, I'll really not have the time to get even a remote sense of living in the city during my short stay so I won't even try. I probably won't do the ultra touristy stuff like Alcatraz (no time) but I'll definitely go to GG bridge and probably also Fisherman's Wharf. I've actually been to SF before with my family when I was 14 and I do remember how touristy Fisherman's Wharf is but my girlfriend hasn't been so we'll probably go there to have a look.
While I'm generally not much into doing touristy stuff in general I also don't think I'm too cool for it. In this particular case SF will 'only' be the final destination of a California road trip along the shore so I'll have had lots of chances to mingle with all sorts of Californians during this time.