Well, I tried a very quick and very unscientific comparison of the manufacturer's scan software (Epson Scan), Vuescan, and SilverFast on 2 photos. I shot some Fuji Superia X-Tra 400 in a Nikon F3 with a 50mm f1.8 Series E lens in partly cloudy conditions. I scanned them with an Epson Perfection V600. I don't know if some features are unavailable in the trial versions of either application, so please let me know if these don't match what you get.
First is Epson Scan with some unsharp mask and dust removal. This scan has overall the best color, to me.
Canon Test Epson Scan
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Cry Baby Lane, on Flickr
Next is the Vuescan version, which I think has a blue cast. I was impressed with the light infrared dust removal setting, I had to set Epson Scan to high to match it.
Canon Test Vuescan
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Cry Baby Lane, on Flickr
Finally is the SilverFast version, which has an orange cast to it. I don't think it was actually allowing me to scan at DPI 3200 like I did with the other two. I had NegaFix set to the proper film for both scans, so I don't know why they look the way they do.
Canon Test SilverFast
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Cry Baby Lane, on Flickr
Overall in the first group, I think the Epson Scan clearly wins.
For the next group, this is the Epson Scan image. This is also representative of the quality I normally get from Epson Scan.
Stream Test Epson Scan
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Cry Baby Lane, on Flickr
Next is Vuescan again. It came out blueish again, although it looks more like the light I remember from that day, as this second one was taken late in the afternoon.
Stream Test Vuescan
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Cry Baby Lane, on Flickr
In this SilverFast scan, the colors are suddenly way punchier even though this was set to the correct NegaFix setting as before and matching USM/dust removal as close as could be to the others. I'm not sure what's going on in the darkest parts of the pictures. I feel like I used SilverFast incorrectly.
Stream Test Silverfast
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Cry Baby Lane, on Flickr
Currently I'm not all that swayed to switch to anything else. I was impressed with the speed at which Vuescan and SilverFast worked at 3200 DPI and with the dust cleaning from Vuescan, but Vuescan's film profiles are super old and don't match most modern films and SilverFast just produced weird scans. Please share your thoughts!