I mostly ignored the controls on my Nikon D300, but my new D7200 has two user settings on the control knob that I have set for the two most common uses I have for the camera, and that's been a nice thing to have. One's set for studio strobe shots, low EI, full manual control; the other for high EI B&W, A priority, which are the only two things I'm usually doing with it. If I had one more user setting I'd set it to EI400, A priority, Auto white balance, and I'd never look at a menu again. Like others, I'm still using center-weighted metering, and for AF, a single center spot, lock and recompose. The Nikons do incredible focusing tricks, but I haven't figured them out. Actually, most of my lenses (bought after I got the D300) are old manual focus primes, so I rarely use any of the DSLR focus modes, anyway.
I know I could fuss with things a lot more, but I'm more interested in not fussing, so I don't. You just have to learn to ignore things. For instance, I don't shoot raw. It's an extra bother, with theoretical advantages, but who are we fooling: the Nikon does jpegs WAY better than my M3s and M4s and Tri-X, and I lived with that level of quality for 40 years just fine. Do I actually need another 5%? No, I do not.
I've messed around with the menus enough to know where it all is, and set up some custom menus, but I view the D7200 the same as PhotoShop--it will do things I never need to do, and I don't need to understand every feature.
Aside from Leicas, my other 35mm film cameras are Nikon FGs. I have never felt that I needed anything more the the basic Leica offered than an OK meter, and so the FG is perfect. I never had any interest in the fancier film Nikons. The FGs stay on A about 100% of the time. When I am carrying Leicas I don't use a meter and haven't for decades--if I have to pull one out, that's too much bother. Even when I was shooting news I never used a motor--line up one good shot, no spray and pray--so that's all unexplored on the new cameras, too.