Jamie123
Veteran
That was my first thought. The other could be double-profiling (or misprofiling), very common problem. I'm not sure how Microsoft-ish Apple has gone with their latest OS (they certainly have with iTunes and QuickTime), so I don't know if this is an option anymore: check with your Color control panel if you have a profile set for your monitor, then check what you're using with VueScan, then check if you're doing a profile conversion vs. adding vs. not doing anything at all with (let's assume you're using) Photoshop.
As I said, it's with color neg film and infrared cleaning turned off. I don't think it's the profile. I have my screen running on a calibrated profile and set Vuescan to run on the same screen profile. Output profile is Adobe RGB if I remember correctly (I'm on another computer right now).
I always convert (not assign) to sRGB as a last step in Photoshop but that's a moot point as the problem I'm having with Vuescan is there from the start (even in the preview) not just after I save the file.