Generally, one rinses the negs for 12 - 20 minutes in clear running water, then drains the tank, fills it up with wetting agent diluted to the strength suggested, then let it sit for 30 seconds or so. Then drain and hang your negs to dry.
Wetting agent's only job is to change the surface tension of the water clinging to the negs, so that they do not stay in droplets on your film as they dry - that causes water spots.
It is the same effect when you take your car to the car wash. If you don't get the water off before it dries, you get water spots. Another alternative some car washes provide is wetting agent.