For holiday travel my typical setup is a Bronica RF645 with 45, 65 and sometimes the 100mm lens. The 45mm lens gets used the most (close to 28mm on 135). Like others, I don’t rely exclusively on MF. I almost always take my Pany GF1 with 40 & 14mm lenses (both are really tiny) and use it for casual snaps and family. This all fits comfortably in a Hadley Pro along with the usual bits and pieces.
Depending on how I’m travelling, I may take a monopod for the Bronica. Early morning or evening shots in lower light need more stability than hand-holding can give, but apart from that the slower aperture lenses are never a problem.
With this combination, I never miss a 35mmm film camera. The higher quality of MF make this an easy decision, and the Bronica is so compact for MF that it’s a delight to use. One more thing, I nearly always use slide film when travelling. For what I like to photograph, high speed lenses and film aren’t necessary, and if I need low light capability – the Pany can do that with more flexibility than film. Best single piece of advice – travel light.
Steve