Once upon a time I used to be a gear taliban and I believed in the old Ansel Adams' saying that it is good to alway have "The largest camera one can carry" so I did it several times but I was sizing down from large format.
- Did the weight slow you down?
Yes, but at that time I didn't have that feeling exactly because I was coming from LF.
Were lenses too slow without using a tripod?
I had a tripod and I was using it even when it was not strictly necessary, I think most of the times it was necessary but I didn't worry much about fast lenses, I guess that it is pretty easy to use hand held a f2.8 Rolleiflex or something of that sort.
Did you wish you had brought with you 35mm camera instead or a digital camera?
At the time I didn't but now I simply cannot imagine to go out without a digital camera.
Why don't you just try it, as the answers show this is not going to kill you and after that you will know if it works for you or not. All is so subjective, so what would you get out of knowing that I get much better images with a digital camera and artificial light, it is you who is going to travel...not me. Don't let people's "knowledge" destroy your pleasure of doing experiments, in photography you are not going to harm mice or anything of that sort so just go out and have fun!
GLF